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An amine-reactive fluorescent probe; ex/em = 502/511 nm; has been used in the synthesis of protease substrates that are non-fluorescent until unquenched following proteolytic cleavage; has been used in the synthesis of a fluorescent verapamil derivative and of fluorescent inhibitors of cholesterol absorption
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Uridine triacetate (Tri-O-acetyl uridine) is an orally active prodrug of Uridine. It is quickly absorbed in the gut and rapidly deacetylated in the circulation to yield free uridine. It is used for the research of 5-fluorouracil (5-FU) and capecitabine toxicity, or early-onset cardiac or central nervous system (CNS) toxicity.
Orally active prodrug of uridine.
Quickly absorbed and deacetylated in circulation.
Used for research of 5-fluorouracil (5-FU) and capecitabine toxicity.
Used for research of early-onset cardiac or central nervous system (CNS) toxicity.
Inhibits [3H]uridine uptake in ENT1 and ENT2 overexpressed HeLa cells.
Improves survival and reduces toxicity in 5-FU overdose mice.
Improves survival and reduces toxicity in DPD deficiency mice.
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Ralaniten triacetate (EPI-506) is a pro-drug of ralaniten and an orally active small-molecule inhibitor of the androgen receptor N-terminal domain (NTD) used in preclinical research on castration-resistant prostate cancer. It inhibits AR transcriptional activity, including resistance-related AR species such as AR-v7, and is supplied for laboratory research use only.
Triacetin is a triester of glycerin and acetic acid that occurs naturally in papaya. It is mainly used as a synthetic flavoring agent in ice-creams nonalcoholic beverages and baked goods.
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Glyceryl monostearate (GMS) is a single-tailed lipidic monoglyceride. It can be used to synthesize nanoliposomes for drug delivery applications. This compound targets liposomes and is involved in the metabolic enzyme/protease pathway.
Used for synthesizing nanoliposomes
Suitable for drug delivery research
Acts as a monoglyceride
Research use only
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Tributyrin (CAS 60-01-5) is a triglyceride ester of butyric acid that functions as a prodrug delivering butyrate upon hydrolysis Butyrate is known to act as a histone deacetylase (HDAC) inhibitor thereby modulating gene expression and promoting cellular differentiation and apoptosis Tributyrin has been investigated in preclinical and clinical studies for its potential to inhibit tumor growth including applications in prostate cancer and adult solid tumors Due to its ability to release bioactive butyrate in vivo it serves as a valuable tool compound for studying epigenetic regulation and cancer therapeutics
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